What is Tryptomer?

Amitriptyline (Elavil, Endep, Levate, and many others) is the most widely used tricyclic antidepressant (TCA). Amitriptyline is chemically basic and is in the form of hydrochloride salt (pKa 9.4) in the market. It is used to treat a number of mental disorders, including major depressive disorder and anxiety, and less commonly psychosis, attention deficit hyperactivity disorder, and bipolar disorder. Side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, and a number of heart issues. It was originally developed by Merck, first synthesized in 1960 and first approved by the US Food and Drug Administration (FDA) on 7 April 1961. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.