Tolbutamide

What is Tolbutamide?

Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.

Questions and answers on "Tolbutamide"

Hello Doc,

I am 31 year old Male and i am diabetic,currently my blood sugar were high as much as 300 plus and My regular doc has asked me to take...

doctor1 MD

Hello XXXXXXX

Thank you for posting on healthcaremagic.

Your weight loss and blood glucose levels suggest you need revised insulin dosages and...

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my blood sugar is 230 this morning and for the past two weeks it has been high. I was taking metformin but I cannot take it each time i take it i...

doctor1 MD

Dear sir i can understand your concern.

Metformin is a very good but the most common side effect is gastric intolerance.

I suggest you to consider...

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My father is diabetic. he has low sugar problem. Nowadays his heels pain a lot while walking or driving. Even his eyes become blood shot lots of...

doctor1 MD

Hi,

Thanks for posting your query.

I can understand your concern for your father.

Having pain in heel is very common diabetics. I hope you have...

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Recent questions on  Tolbutamide

doctor1 MD

Doctor,i am a dibetic patient for 17 years.i am 64 years old.last time when i went for condultation my diabetologist has prescribed JALRA 50/500.mY...

doctor1 MD

my blood sugar is 230 this morning and for the past two weeks it has been high. I was taking metformin but I cannot take it each time i take it i...

doctor1 MD

My blood sugar levels are from 230 -261. They were 600 without taking metformin(I take metformin two tables twice a day). My doctor also wanted to...

doctor1 MD

is there any relation ship between diabetics injection insulin and nerves in our blood stream, my sister is taking insulin for diabetics but she is...

doctor1 MD

hello sir , myself 45 yr male suffering from diabetes for last 5 yrs. using Glucored forte - twice & day & PIOZ mf 30 also twice a days but my...

doctor1 MD

I have complete report of get test,fasting blood sugar was noted to be 97mg/dl,i was given 75 glucose and after one hour the blood sugar was noted...

doctor1 MD

SIR/MADAM, I AM AGED 40 YEARS, DETECTED OF DIABETES TYPE II FOR THE LAST 2 YEARS, PROBLEM 1) TREMENDOUS "RAPID GASTRIC DUMPING" AND NAUSEA 2) MY...

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