What is Tolbutamide?

Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.

Questions and answers on "Tolbutamide"

Hello Doc,

I am 31 year old Male and i am diabetic,currently my blood sugar were high as much as 300 plus and My regular doc has asked me to take...

doctor1 MD


Thank you for posting on healthcaremagic.

Your weight loss and blood glucose levels suggest you need revised insulin dosages and...

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my blood sugar is 230 this morning and for the past two weeks it has been high. I was taking metformin but I cannot take it each time i take it i...

doctor1 MD

Dear sir i can understand your concern.

Metformin is a very good but the most common side effect is gastric intolerance.

I suggest you to consider...

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My father is diabetic. he has low sugar problem. Nowadays his heels pain a lot while walking or driving. Even his eyes become blood shot lots of...

doctor1 MD


Thanks for posting your query.

I can understand your concern for your father.

Having pain in heel is very common diabetics. I hope you have...

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