Temodar

What is Temodar?

Temozolomide, (TMZ) (brand names Temodar and Temodal and Temcad) is an oral chemotherapy drug. It is an alkylating agent used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme — as well as for treating melanoma, a form of skin cancer. Temozolomide is also indicated for relapsed Grade III anaplastic astrocytoma and not indicated for, but used to treat oligodendroglioma brain tumors in some countries, replacing the older (and less well tolerated) PCV (Procarbazine-Lomustine-Vincristine) regimen.

The agent was developed by Malcolm Stevens and his team at Aston University in Birmingham, Temozolomide is a prodrug and an imidazotetrazine derivative of the alkylating agent dacarbazine. It has been available in the US since August 1999, and in other countries since the early 2000s.

The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions of guanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing a protein O6-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. Conversely, the presence of AGT protein in brain tumors predicts poor response to temozolomide and these patients receive little benefit from chemotherapy with temozolomide.

Questions and answers on "Temodar"

My wife was diagnosed with glioblastoma multiforme IV on September 26, 2010, had the tumor successfully resected on September 20, 2010, went...

doctor1 MD

because temozolamide is highly myelosuppresive effects that causese bone marrow supression.while on radiaton it given continuosly along with...

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just wondering how much this will cost me. My son has anaplastic oligodendroglioma, grade 3 in his cerebellum. His surgery is 80% partial and...

doctor1 MD

Hi,

Sense of tiredness can persist from 6 months to 2 years following Temodar exposure... stress in the body and could signify an elevation in...

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Skipping or delaying a dose of Temodar?
I have a Glioblastoma stage 4, discovered 10 months ago Dr. operated 1 week later. Did standard 33 day...

doctor1 MD

Hi. I would advise you not to skip a dose or delay it. You can take the medicine while working. your medicine is to be taken by mouth. Many of my...

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Recent questions on  Temodar

doctor1 MD

just wondering how much this will cost me. My son has anaplastic oligodendroglioma, grade 3 in his cerebellum. His surgery is 80% partial and...

doctor1 MD

I've been diagnosed with a Grade III Glioma , diffuse astrosystoma...I'm to begin Temodar 100mg for 42 days, then 5 days on and 22 days off after....

doctor1 MD

My wife was diagnosed with glioblastoma multiforme IV on September 26, 2010, had the tumor successfully resected on September 20, 2010, went...

doctor1 MD

I have developed severe cystic acne since starting Temodar. In the past I developed cystic acne as a response to stress/anxiety, however it was...

doctor1 MD

I have developed severe cystic acne since starting Temodar. In the past I developed cystic acne as a response to stress/anxiety, however it was...

doctor1 MD

MY PLATELET COUNT WAS ABOUT 85 ON FRIDAY AND TODAY IT IS 112. I DRANK A BIT OF WATER OVER THE WEEKEND. WHAT IS THE BEST WAY TO GET THE NUMBER UP...

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