What is Santyl?

Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.

Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.

In addition to being produced by some bacteria, collagenase can be made by the body as part of its normal immune response. This production is induced by cytokines, which stimulate cells such as fibroblasts and osteoblasts, and can cause indirect tissue damage.

Questions and answers on "Santyl"


doctor1 MD

Brief Answer:
The wound should be cleansed with sterile saline before applying santyl

Detailed Answer:
Hi and thank you so much for this query....

Read Full Thread   Ask a Doctor Now

Do you know of an alternative and effective medicine to Santyl*Collagenaes).I have chronic wounds on my left and right ankles. But Santyl is too...

doctor1 MD

Brief Answer:
You can try antibiotic coated dressing.

Detailed Answer:
Thanks for trusting Healthcaremagic!
I have gone through your query...

Read Full Thread   Ask a Doctor Now

How effective is Santyl for bed soresy

doctor1 MD

Brief Answer:
Very effective.

Detailed Answer:
Thanks for your query, albeit very small and specific.

Santyl is very effective in treatment of...

Read Full Thread   Ask a Doctor Now

Recent questions on Santyl

Ask Question
Doctor Image

Hi, I am Dr. Andrew Rynne (Family Physician). I will be guiding you through the process. Please write your question below.

Related Drugs/Medications
Related Lab Tests
Related Procedures
Related Medical Topics