What is Probucol?

Probucol is an anti-hyperlipidemic drug initially developed in the treatment of coronary artery disease.

However, clinical trials were stopped after it was found that it may lower HDL in patients with a previous history of heart disease.

Probucol was initially developed in the 1970s by a chemical company to maximize airplane tire longevity. Probucol is associated with QT interval prolongation.

Probucol lowers the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant which inhibits the oxidation of cholesterol in LDLs; this slows the formation of foam cells, which contribute to atherosclerotic plaques.

Questions and answers on "Probucol"

What can I do diet wise for my husband who had bloodwork done by LifeLine screening and they gave him his cholesterol numbers-- HDL was 15, they...

doctor1 MD

Hello and thank you for sending your question.

This is a very good question.

You indicated that your husbands HDL-cholesterol is very low....

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When I sleep the night after consuming alcohol I begin to fall asleep then almost jump start myself awake, heart rate is high then relaxes can...

doctor1 MD


Thanks for writing your query.

It will be helpful if you please answer the following:-
1. Are you a regular drinker or an occasional drinker?...

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iam 35 years old, male, 5,3" i weigth 160 lbs, and i have high blood pressure for the last 2 years and i recently i did a lab exam and so tells that...

doctor1 MD

You have symptoms of various systems. So i recommend you to get them all evaluated.
About your bp & cholesterol, it would be better if...

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