Prezista

What is Prezista?

Darunavir (brand name Prezista, formerly known as TMC114) is a protease inhibitor drug used to treat HIV infection. Prezista is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents. Developed by pharmaceutical company Tibotec, darunavir is named after Arun K. Ghosh, the chemistry professor who discovered the molecule at the University of Illinois at Chicago. It was approved by the Food and Drug Administration (FDA) on June 23, 2006.

Darunavir is a second-generation protease inhibitor (PIs), designed specifically to overcome problems with the older agents in this class, such as indinavir. Early PIs often have severe side effects and drug toxicities, require a high therapeutic dose, are costly to manufacture, and show a disturbing susceptibility to drug resistant mutations. Such mutations can develop in as little as a year of use, and effectively render the drugs useless.

Darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including strains from treatment-experienced patients with multiple resistance mutations to PIs.

Darunavir received much attention at the time of its release, as it represents an important treatment option for patients with drug-resistant HIV. Patient advocacy groups pressured developer Tibotec not to follow the previous trend of releasing new drugs at prices higher than existing drugs in the same class. Darunavir was priced to match other common PIs already in use, such as the fixed-dose combination drug lopinavir/ritonavir.

Questions and answers on "Prezista"

I currently take Prezista, Norvir and Triumeq as my HIV combination pills.
My CD4 numbers have been very good and my Viral Load is undetectable....

doctor1 MD

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Follow the guidelines of your physician.

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Welcome to HCM
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In the presence of...

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Hi there. I am on HIV combination medication truvada, prezista and norvir? I work night duty but am finding it hard to sleep. I have bought kalms...

doctor1 MD

Brief Answer:
Drug interaction can occur with other medications.

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Hi,
Welcome to XXXXXXX
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The...

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Im a 28 yr old Caucasian male hiv+ as of March 2010 and undetectable for years with a cd4 in the high 500s. currently taking truvada prezista...

doctor1 MD

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Thank you for posting your query.

Based on the information you have provided, the most likely cause for the lesion in the cerebellum would be a...

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Recent questions on  Prezista

doctor1 MD

I currently take Prezista , Norvir and Triumeq as my HIV combination pills. My CD4 numbers have been very good and my Viral Load is undetectable....

doctor1 MD

Hi, I have had aids for 15 years. I was in clinical trials at the university of Pittsburgh for 6 or 7years and took the 15 drugs available at that...

doctor1 MD


1-Is there a complete cure for AIDS disease?
2-Where can I find complete cure for AIDS in the world or USA?
3-Where is the best place for treating...

doctor1 MD

Taking Stribild , Tivicay, Sustiva, & Prezista . End of my rope. That explains the cocktail. Symptoms: unusual pain in legs and buttocks. Also...

doctor1 MD

Hi there. I am on HIV combination medication truvada , prezista and norvir? I work night duty but am finding it hard to sleep. I have bought kalms...

doctor1 MD

Im a 28 yr old Caucasian male hiv+ as of March 2010 and undetectable for years with a cd4 in the high 500s. currently taking truvada prezista...

doctor1 MD

under my fore skin is very red and very itchy, it also feels and looks moist even when I dried it after washing (aquas cream, never soap), my...

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