Polymyxin b sulfate

What is Polymyxin b sulfate?

Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is composed of a number of related compounds (see "Mixture composition"). It has a bactericidal action against almost all Gram-negative bacilli except the ''Proteus'' and Neisseria genera. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. Polymyxins are cationic, basic peptides that act like detergents (surfactants). Side effects include neurotoxicity and acute renal tubular necrosis. Polymyxins are used in the topical first-aid preparation Neosporin.

  1. Family of polypeptides with attached fatty acid; cationic detergent at physiological pH, both hydrophilic and hydrophobic properties
  2. Bactericidal for gram-negative; little to no effect on gram-positive, since cell wall is too thick to permit access to membrane

Questions and answers on "Polymyxin b sulfate"

six days ago I woke up with my left eye feeling like it something in it. After eye washing and drops it felt no better. I had a tube of neomycin...

doctor1 MD

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It seems from the history that you are having sudden onset of redness of eyes. This can be because of infection of the eyes in the form of...

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I am allergic to sulfa drugs and penicillin. But I'm schedule for cataract surgery on Monday and am asked to begin taking POLYMYXIN-B...

doctor1 MD

Brief Answer:
Yes if you are allergic to sulfa drugs please dont take these .

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I am Dr Rahul Rathee and it will...

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My daughter is 21 months old, from past few days i am observing paper put between her vagina and anus (pic is attached). She wears Mamy Poco Pants...

doctor1 MD

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Application of anti fungal ointment will be helpfu

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Welcome to Healthcare-Magic
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Dear Mr...

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Recent questions on  Polymyxin b sulfate

doctor1 MD

Hi, I have a cut on my finger and used a triple antibiotic first aid ointment. I am 4 weeks pregnant. Is the ointment harmful for my baby?

doctor1 MD

I am allergic to sulfa drugs and penicillin. But I'm schedule for cataract surgery on Monday and am asked to begin taking POLYMYXIN-B...

doctor1 MD

I have the worse "Pink Eye" ever - so Nurse Practitioner put me on Trimethoprim Sulfate with Polymyxin B Sulfate Eye Drops 4 Xs Day plus...

doctor1 MD

Hi, I m Mary Ann. I just scraped my elbow. It bled some. What antibiotic cream can I use on it, since I have both a sulfa allergy and sulfite...

doctor1 MD

six days ago I woke up with my left eye feeling like it something in it. After eye washing and drops it felt no better. I had a tube of neomycin...

doctor1 MD

Will Polymyxin B sulfate eye drops 2 can cause allergic reaction? What are the symptoms versus a real conjuntivities? I am allergic to Neosporin,...

doctor1 MD

I just cut my middle knuckle on my middle finger this morning, little deep cut compared to a paper cut. Ran it under cold running water , rubbed it...

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