What is Podophyllin?

Podophyllin is a resinous powder obtained by precipitating an alcoholic tincture of the rhizome of American Mayapple (Podophyllum peltatum) or Podophyllum emodi by means of water acidified with hydrochloric acid. It varies in color from grayish to bright yellow or greenish-brown, the first-named being the purest. It was once commonly used against HPV-induced genital warts because it contains antiwart lignans. Podofilox, a purified form of the main active ingredient, is currently recommended instead due to its higher efficacy and safety.

The powder is soluble in alcohol and strong solutions of alkalis, such as ammonia. Its composition is somewhat complex. There are certainly at least two resins in the powder (which is known officially as Podophylli resina), one of them being soluble and the other insoluble in ether. Each of these contains an active substance, which can be obtained in crystalline form, and is known as podophyllotoxin. It is soluble in alcohol, ether, chloroform and boiling water.

Questions and answers on "Podophyllin"

Hi, Varucca plana was detected on my son's face and arms who is 6 years old.
Spots are now increasing on both arms.
pls suggest treatment
Thanks for posting query.
Varucca plana is also called flat wart.
Mostly this will clear its own within few months or years.
If warts are increasing in numbers he may go for any of the following procedures. A competent dermatologist can examine and suggest the best one for you.
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i have had genital warts for a cpl yrs and the freeze method isnt working. it comes bk in a matter of weeks and leaves scarring. it tells me this method isnt working for me. ive read reports of aldara working but also reports giving neg feedback about the product. im wondering if 'wartol' mouth spray is TRULY effective or if its a scam.


Genital wart is caused by human papilloma virus.

The treatment methods include medication like [ Imiquimod (Aldara), Trichloroacetic acid (TCA), Podophyllin and podofilox (Condylox)]

Or you can go for the surgical procedures like ( Cryosurgery, electrocauterization, laser therapy,...

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Hello Doctor, I have genital warts on my penis shaft, I had done cryotherphy (liquid nitrogen) about 6 months ago but it reappeared again in same please and more around the treated area, i had stopped having sex with anyone for past 5 months, had done twice HIV test negative, but this really worries me a lot, i have a family and am growing in business, whenever I see this warts I get so worried and feeling like dying, the worst is now I just seen very tiny spots at the top of the penis....Is there anyway I can get rid of these genital warts and stop further spread, please help me....

Thanks for sharing your queries with us.

Genital warts are a common problem in both males and females. They are caused by HPV which is sexually transmitted. Once transmitted, they proliferate and cause a growth in the genital area, which we call warts.

There are several methods of...
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tell me more about human papillomavirus\
Hi Art!

Welcome to papillomavirus (HPV) is a member of the papillomavirus family of viruses that is capable of infecting humans. Like all papillomaviruses, HPVs establish productive infections only in the stratified epithelium of the skin or mucous membranes. The...
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I have what seems like less than pea size lump over the shaft of my penis ... this has developed in past 2-3 months.. doesnt pain ... no itching ... is there any ointment i can use for the removal
Thanks for your query.

From your description it appear that you probably have Molluscum contagiosum. It is caused by viral infection of skin by virus. It is usually a dome-shaped, pink, waxy papules that are 2-5 mm in diameter with pitting/dimple/umblication on top.

In your case diagnosis...
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I have some strange condition, first noticed about 5 years ago, from what I can remember. On the left side of my scrotum i have "swollen pores" hard white bumps. Every once in awhile, one will get a little larger, and I will sqeeze it till it 'pops'. a non liquid, white substance comes out. What is this? is there treatment? Only thing I can remember from around that time was my girlfriend at the time told me that she went to the doctor and had a "ovarian sist" and that the doctor diagnosed her with HPV.. I always wore protection with her, however my scrotum was exposed.. we broke up soon after she told me about this. is it possible it could be from that?
Yes it could be an HPV virus infection on your scrotum.HPV infection can cause genital warts and some cancers in the anogenital region.They are transmitted through sexual contact.
Condoms do not protect from the virus because the areas around the genitals including the inner thigh area are not...
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I have small white dots on either side of my frenulum. No pain or itching, well defined borders, no redness, slightly raised. Diagnosed with hpv 6 months ago at a different location on the shaft. I had some podophilotoxin left so I applied it to one of the new warts (as I assumed thats what they were). 1 week of application, then one week after the wart is bigger with the original central dot. What could this be?
hi and thanks for the question,
Hypopigmentation or hyperpigmentation of the skin with podophilotoxin are some side effects which are seen in some situations. Podophilotoxin
should be applied to each wart and allowed to air-dry before the treated area comes into contact with clothing;...
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3 months ago I found a tick between my crotch, I pulled the tick out but I noticed discoloration next to where the tick was. Later some forskin developed and after that the forskin has grown and turned grey. Its been 3 months since the tick bite and one month wherer the developed forskin has grown. Lkittle and changed color. 27 year old male

Thanks for your query.

I would like to know some details on your problem so that I understand better and provide you specific advice.

Was there redness after you removed the tick ?
Can you describe the foreskin you mentioned in some more detail ?
Did you have itching soon after the lesion...
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i have warts on my penis. a doctor has been applying podowart twice a week for two months but they havent gone please help thanks a ton

Welcome to Health Care Magic.
Thanks for posting your query.

May I ask you few questions before I answer your query?
1. After application of podowart whether the lesions regressed and reappeared or not at all responding?
2. Are you a diabetic or immuno-compromised?
3. What is the size of...
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I developed a genital mole on 2005 and because it was itching I scratched it and it came off with lots of bleeding. After that the mole disappeared but a year later another one showed which I was afraid to scratch it and it has been there since then (8 years, see attached photo).
So I went to a dermatologist 6 years ago and she told me it was nothing that I should not worry but today while reading some articles about genital diseases I found that it could be a "genital wart" which I understand is a Human Papillomavirus (HPV) infection.

Can you please advise what I might have?. The mole itches sometimes, but not all the time and it has not bother me but now I am worried about it.
Are there any creams or treatments I can use to get rid off it?.

I have "fatty liver" so I would not like to take any medication that will affect my liver.

Thank you very much.
Brief Answer:
It look like a wart. The rough surface is suggestive!

Detailed Answer:
Hi and thank you so much for this query.

I am so sorry to hear about this lesion that you have reported. I have taken a look and it is very suggestive of a wart from its features. The best way is to scrape it...
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