Phenobarbitone

What is Phenobarbitone?

Phenobarbital (INN) or phenobarbitone (BAN) is a long-acting barbiturate and the most widely used anti-seizure medication globally. It has sedative properties, but as with other barbiturates, benzodiazepines are more commonly used for this purpose. Phenobarbital produces sedation by increasing the proportion of bound GABA receptors that are in the long-duration active state.

The World Health Organization recommends phenobarbital as a first-line medication for partial and generalized tonic–clonic seizures in developing countries. In the more developed world, it is no longer recommended as a first- or second-line choice for most seizure types, though it is still commonly used to treat neonatal seizures. The injectable form is mostly used to control status epilepticus, while by mouth it is used to prevent seizures in people with epilepsy. It is occasionally used to treat an inability to sleep, anxiety and to help with drug withdrawal as well as surgery.

Side effects include a decreased level of consciousness along with a decreased effort to breathe. There is concern of both abuse and withdrawal following long term use. It may also increase the risk of suicide. It is pregnancy category B or D in the United States and category D in Australia, meaning that it is may cause harm when taken by pregnant women.

It is a core medicine in the WHO Model List of Essential Medicines, which is a list of minimum medical needs for a basic health care system. It is the oldest still commonly used anti-seizure medication having first been sold in 1912.

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My 4 months old daughter is crying a lot by birth.
Doctors gave the medicines for meningitis but no improvement seen. only the tremble of her body...

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I am sorry to say this but the prognosis is poor

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Today we conduct an EEG test for my nephew who is 2 year old male. below are the details.

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EEG Obtained with 10-20 system of electrode...

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EEG findings interpretation

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OK ...what benzo is safest (and dose) to rapidly reduce a patient off 224 mgs of phenobarbital due to adverse reactions

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Today we conduct an EEG test for my nephew who is 2 year old male. below are the details. Heading: EEG Obtained with 10-20 system of electrode...

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Hi, Myself xxxxx. We had a baby boy on 17th XXXXXXX 2016 with weight 3.98 KGS. So far so good, later on 26th XXXXXXX midnight suddenly he got fits...

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Hi, I am writing from Mongolia. My son is 2 months old and he has cold now, sore throat, coughing and running nose and watery eyes. it has been 2...

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