What is Nicorandil?

Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Angedil (in Romania, Poland), Dancor (in Switzerland), Nikoran,PCA (in India), Aprior (in the Philippines), Nitorubin (in Japan), and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.

Angina is chest pain that results from episodes of transient myocardial ischemia. This can be caused by diseases such as atherosclerosis, coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to increased calcium sensitivity and hypercontraction. Rho-kinase also decreases nitric oxide synthase activity, which reduces nitric oxide concentrations. Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic vascular smooth muscle cells, which could result in excessive calcium influx, and hypercontraction.

Nicorandil is an anti-angina medication that has the dual properties of a nitrate and K+ATP channel agonist. At high plasma concentrations nicorandil reduces coronary vascular resistance, which is associated with increased K+ATP channel opening.

Questions and answers on "Nicorandil"

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doctor1 MD

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Yes , If you take Only carvedilol, Viagra can be taken safely

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My dad aged 96 .active person for his age.known hypertensive for the last 20 years .taking anti-hypertensives as per docs adv.Family...

doctor1 MD

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Age-induced changes in all systems

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My father has Coronary Artery Disease and he has been taking following medications for about five years: diltiazem, enalapril and nicorandil....

doctor1 MD

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yes there are other medications

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