Nicorandil

What is Nicorandil?

Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Angedil (in Romania, Poland), Dancor (in Switzerland), Nikoran,PCA (in India), Aprior (in the Philippines), Nitorubin (in Japan), and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.

Angina is chest pain that results from episodes of transient myocardial ischemia. This can be caused by diseases such as atherosclerosis, coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to increased calcium sensitivity and hypercontraction. Rho-kinase also decreases nitric oxide synthase activity, which reduces nitric oxide concentrations. Lower levels of nitric oxide are present in spastic coronary arteries. L-type calcium channel expression increases in spastic vascular smooth muscle cells, which could result in excessive calcium influx, and hypercontraction.

Nicorandil is an anti-angina medication that has the dual properties of a nitrate and K+ATP channel agonist. At high plasma concentrations nicorandil reduces coronary vascular resistance, which is associated with increased K+ATP channel opening.

Questions and answers on "Nicorandil"

I take 3.25 mg a day of carvedilol is it safe for me to take a 50 mg of viagra?

doctor1 MD

Brief Answer:
Yes , If you take Only carvedilol, Viagra can be taken safely

Detailed Answer:
Hello ,
I am Dr. Mody and I would be addressing your...

Read Full Thread   Ask a Doctor Now

dear doctor

My dad aged 96 .active person for his age.known hypertensive for the last 20 years .taking anti-hypertensives as per docs adv.Family...

doctor1 MD

Brief Answer:
Age-induced changes in all systems

Detailed Answer:
Greetings and welcome to HCM. Thank you for your question. I understand your...

Read Full Thread   Ask a Doctor Now

Hi,

My father has Coronary Artery Disease and he has been taking following medications for about five years: diltiazem, enalapril and nicorandil....

doctor1 MD

Brief Answer:
yes there are other medications

Detailed Answer:
Hello,
I am sorry your father has been having so many problems. The most likely...

Read Full Thread   Ask a Doctor Now

Recent questions on  Nicorandil

doctor1 MD

hi doctor I had MI before 3.5 years . I TAKEN HYPERTENSIVE MEDICINES + blood thinner REGULARLY. I suffered nasal bleeding also and was critically...

doctor1 MD

dear doctor My dad aged 96 .active person for his age.known hypertensive for the last 20 years .taking anti-hypertensives as per docs adv.Family...

doctor1 MD

I take 3.25 mg a day of carvedilol is it safe for me to take a 50 mg of viagra?

doctor1 MD

Hi, My father has Coronary Artery Disease and he has been taking following medications for about five years: diltiazem , enalapril and nicorandil ....

doctor1 MD

I was given Nikoran 10 mg after angeography .I had it for two yrs. Since the last five days I am having severe headache . Theis could be due to the...

doctor1 MD

hello my mother is suffering from chest pain since 3 months dr prescribed her with nikoran 10 tab but after taking that she has developed white...

Ask Question
Doctor Image
MD

Hi, I am Dr. Andrew Rynne (Family Physician). I will be guiding you through the process. Please write your question below.

Related Drugs/Medications
Related Treatment/Therapy
Related Procedures
Related Medical Topics