What is Meglitinide?

Meglitinides (glinides) are a class of drugs used treat diabetes type 2.

They bind to an ATP-dependent K+ (KATP) channel on the cell membrane of pancreatic beta cells in a similar manner to sulfonylureas but have a weaker binding affinity and faster dissociation from the SUR1 binding site. This increases the concentration of intracellular potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.

Questions and answers on "Meglitinide"

What diabetic drugs does garcinia cambogia interact with? and are there any dangerous side effects.

doctor1 MD

Brief Answer:
About garcinia cambogia:

Detailed Answer:
Hello and thank you for asking!
Garcinia cambogia boosted fat-burning and cut back appetite...

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Im borderline stage two kidney disorder and a diabetic was on Januvia not have 3 goiters in rt lobe of thyroid wont take Januvia any more loking...

doctor1 MD

You have diabetes with early kidney disease and goiter.

Your kidney disease is not so bad. In-fact you can continue ACE-Inhibitors and...

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my mother around 60 years is diabetic & was on with 4mg of glimipride & 1000mg of metformin daily. Her FBS was 210, PPBS 450. Now she was changed...

doctor1 MD

Dear friend, welcome and thanks for entrusting your query here at Healthcaremagic!
I am Dr. Prasad Akole (Critical Care Expert-...

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