What is Jentadueto?

Metformin (BAN, USAN and INN, pronounced , ; sold as Glucophage) is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Its use in gestational diabetes has been limited by safety concerns. It is also used in the treatment of polycystic ovary syndrome, and has been investigated for other diseases where insulin resistance may be an important factor. Metformin works by suppressing glucose production by the liver.

Limited evidence suggests metformin may prevent the cardiovascular and possibly the cancer complications of diabetes. Metformin is one of only two oral antidiabetics in the World Health Organization Model List of Essential Medicines (the other being glibenclamide).

Metformin causes few adverse effects when prescribed appropriately (the most common is gastrointestinal upset) and has been associated with a low risk of having a low blood sugar. Lactic acidosis (a buildup of lactate in the blood) can be a serious concern in overdose and when it is prescribed to people with contraindications, but otherwise, no significant risk exists.

First synthesized and found to reduce blood sugar in the 1920s, metformin was forgotten for the next two decades as research shifted to insulin and other antidiabetic drugs. Interest in metformin was rekindled in the late 1940s after several reports that it could reduce blood sugar levels in people, and in 1957, French physician Jean Sterne published the first clinical trial of metformin as a treatment for diabetes. It was introduced to the United Kingdom in 1958, Canada in 1972, and the United States in 1995. Metformin is now believed to be the most widely prescribed antidiabetic drug in the world; in the United States alone, more than 48 million prescriptions were filled in 2010 for its generic formulations.

Questions and answers on "Jentadueto"

Hi I am a fit 70 year old male. My belly sticks out / bloats despite going to gym 3 times a week. i eat healthy and my motions are soft and I don't...

doctor1 MD

Brief Answer:
Diabetic gastroparesis and sequelae

Detailed Answer:
Thank you for asking

I read your question and i understand your concern. Age of...

Read Full Thread   Ask a Doctor Now

I am a 59 year old male having hypertension and diabetes. About a month ago my Micardis HCT 80-12.5 mg was switched to Losartan -HCTZ 50-12.5 mg. I...

doctor1 MD

Thanks for the query to H.C.M. Forum.
The side effect of LOsartan is dizziness ( beside others).
Hydrochlorothiazide and spironolactone are...

Read Full Thread   Ask a Doctor Now

I am a 56 year old male. I have been losing weight without trying (about 50 lbs in the last year). I am overweight. I have had bowel changes...

doctor1 MD

Brief Answer:
Please, do a colonoscopy!

Detailed Answer:
Hi and thank you so much for this query.

I am o sorry about what you have been...

Read Full Thread   Ask a Doctor Now

Recent questions on Jentadueto

Ask Question
Doctor Image

Hi, I am Dr. Andrew Rynne (Family Physician). I will be guiding you through the process. Please write your question below.

Related Disease & Conditions
Related Drugs/Medications