Jantoven

What is Jantoven?

Warfarin (also known by the brand names Coumadin, Jantoven, Marevan, Uniwarfin) is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body, respectively. It was initially introduced in 1948 as a pesticide against rats and mice, and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s, warfarin was found to be effective and relatively safe for preventing thrombosis and thromboembolism in many disorders. It was approved for use as a medication in 1954, and has remained popular ever since. Warfarin is the most widely prescribed oral anticoagulant drug in North America.

Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods (particularly leaf vegetable foods or "greens," since these typically contain large amounts of vitamin K1) and its activity has to be monitored by blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken. A high INR predisposes patients to an increased risk of bleeding, while an INR below the therapeutic target indicates the dose of warfarin is insufficient to protect against thromboembolic events.

Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K1 to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist, warfarin does not antagonize the action of vitamin K1, but rather antagonizes vitamin K1 recycling, depleting active vitamin K1. Thus, the pharmacologic action may always be reversed by fresh vitamin K1. When administered, these drugs do not anticoagulate blood immediately. Instead, onset of their effect requires about two to three days before remaining active clotting factors have had time to naturally disappear in metabolism, and the duration of action of a single dose of warfarin is 2 to 5 days. Reversal of warfarin's effect by discontinuing its use, or by administering vitamin K1, requires a similar period of time.

Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant originally discovered in spoiled sweet clover-based animal feeds. Dicoumarol, in turn, is derived from coumarin, a sweet-smelling but coagulation-inactive chemical found naturally in "sweet" clover (to which it gives its odor and name), tonka beans (also known as "cumaru" from which coumarin's name derives), and many other plants. The name 'warfarin' stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization that funded the key research, "WARF" for the Wisconsin Alumni Research Foundation and the ending "-arin", indicating its link with coumarin.

Questions and answers on "Jantoven"

I have been on Jantoven for 1 1/2 years after experiencing bi-lateral PE's. Since that time I have had heart palpatations. I recently went off...

doctor1 MD

Hi,

Jantoven (warfarin sodium) itself should not cause any palpitations. However, warfarin can cause several drug interactions and increase or...

Read Full Thread   Ask a Doctor Now

My name is Antonietta Di Giacomo and I takelevothyroxin for many years I take Lipitor 10mg know thay give to me the substitute wich is Atorvastain...

doctor1 MD

Hi,
Thanks for using Healthcaremagic,
You are taking medicines Atorvastatin,Levothyroxine,Metoprolol,Nexium,Sertraline,Losartan and...

Read Full Thread   Ask a Doctor Now

side effects of change to Jantoven from warfarin sodium Have developed fatty liver, dark and slow urine, shortness of breath, dizziness, etc....

doctor1 MD

Brief Answer:
Jantoven is warfarin

Detailed Answer:
Hello and thank you for your question.
Jantoven is warfarin sodium so the switch from one brand...

Read Full Thread   Ask a Doctor Now

Recent questions on Jantoven


Ask Question
Doctor Image
MD

Hi, I am Dr. Andrew Rynne (Family Physician). I will be guiding you through the process. Please write your question below.

Related Drugs/Medications
Related Medical Topics