What is Gentamicin?

Gentamicin is an aminoglycoside antibiotic composed of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms.

It is synthesized by Micromonospora, a genus of Gram-positive bacteria widely present in the environment (water and soil). To highlight their specific biological origins, gentamicin and other related antibiotics produced by this genus (verdamicin, mutamicin, sisomicin, netilmicin, retymicin) generally have their spellings ending in ~micin and not in ~mycin. Gentamicin is a bactericidal antibiotic that works by binding the 30S subunit of the bacterial ribosome, interrupting protein synthesis.

Like all aminoglycosides, when gentamicin is given orally, it is not systemically active. This is because it is not absorbed to any appreciable extent from the small intestine. It is administered intravenously, intramuscularly or topically to treat infections. It appears to be completely eliminated unchanged in the urine. Urine must be collected for many days to recover all of a given dose because the drug binds avidly to certain tissues.

E. coli has shown some resistance to gentamicin, despite being Gram-negative. Reluctance to use gentamicin for empirical therapy has led to increased use of alternative broad-spectrum antibiotics, which some experts suggest has led to the prevalence of antibiotic-resistant bacterial infections by MRSA and other so-called "superbugs".

Gentamicin is one of the few heat-stable antibiotics that remain active even after autoclaving, which makes it particularly useful in the preparation of some microbiological growth media. It is used during orthopaedic surgery when high temperatures are required for the setting of cements (e.g. hip replacements).

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Questions and answers on "Gentamicin"

Hello, I got into a fist fight, got hit in my jaw, my whole left side of my face is swollen, and the doctor said that I eyeball was scratched, he...

doctor1 MD

This oint ment can not cause any problem in eye. you can change to neo sporine ophthalmic ointment. you can get his eye examined and review his...

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Hi! I recently had conjunctivitis (pink eye), which is gone now, thanks to antibiotic treatment (Gentamicin) eye drops. My questions is this: Can I...

doctor1 MD

yes you can do that asper instruction. take the opinion of optician, who have provided you the lens there must be instruction in company leaflet.

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Hello, I came down with pink eye a few days ago. My doctor prescribed me Gentamicin Sulfate 0.3%, 1-2 drops twice a day. But the online information...

doctor1 MD

Putting the drops every 4 hours is more than sufficient.
You are not going to get any extra benefit if you start installing drops in your...

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