What is E-mycin?
Erythromycin is an antibiotic useful for the treatment of a number of bacterial infections. It is in the macrolide class and has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often prescribed for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and ''Legionella''. It was first marketed by Eli Lilly and Company, and it is today commonly known as erythromycin ethylsuccinate (EES), a commonly administered ester prodrug. It is commonly applied after delivery to the eyes of newborns to prevent neonatal conjunctivitis. It is used as an alternative treatment to treat sexually transmitted diseases.
Erythromycin improves gastric emptying and symptoms from delayed gastric emptying, yet it is used in an off-label basis. Intravenous (IV) erythromycin Is sometimes administered when IV prokinetic therapy is needed in hospitalized patients. Oral treatment with erythromycin improves gastric emptying, but has limited long-term efficacy.
In structure, this macrocyclic compound contains a 14-membered lactone ring with 10 asymmetric centers and two sugars (L-cladinose and D-desosamine), making it a compound very difficult to produce by synthetic methods. Erythromycin is produced from a strain of the actinomycete Saccharopolyspora erythraea.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.