Cortisone acetate

What is Cortisone acetate?

Glucocorticoids (GCs) are a class of steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. The name glucocorticoid (glucose + cortex + steroid) derives from its role in the regulation of the metabolism of glucose, its synthesis in the adrenal cortex, and its steroidal structure (see structure to the right). A less common synonym is glucocorticosteroid.

GCs are part of the feedback mechanism in the immune system that turns immune activity (inflammation) down. They are therefore used in medicine to treat diseases caused by an overactive immune system, such as allergies, asthma, autoimmune diseases, and sepsis. GCs have many diverse (pleiotropic) effects, including potentially harmful side effects, and as a result are rarely sold over the counter. They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. This includes mainly inhibitory effects on lymphocyte proliferation (treatment of lymphomas and leukemias) and mitigation of side effects of anticancer drugs.

GCs cause their effects by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression).

Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. In technical terms, "corticosteroid" refers to both glucocorticoids and mineralocorticoids (as both are mimics of hormones produced by the adrenal cortex), but is often used as a synonym for "glucocorticoid." Glucocorticoids are chiefly produced in the zona fasciculata of the adrenal cortex, whereas mineralocorticoids are synthesized in the zona glomerulosa.

Cortisol (or hydrocortisone) is the most important human glucocorticoid. It is essential for life, and it regulates or supports a variety of important cardiovascular, metabolic, immunologic, and homeostatic functions. Various synthetic glucocorticoids are available; these are used either as replacement therapy in glucocorticoid deficiency or to suppress the immune system.

Questions and answers on "Cortisone acetate"

for these conditions i take cortisone acetate, florinef, & eltroxin. i m in excellant physical condition otherwise. is it ok for me to take classes...

doctor1 MD

tHANKS for the query

Yes u can participate in scuba diving with whatever the scuba diving risks are present for the general population provided all...

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Can I take cortisone acetate while on blood pressure tablets - karvezide.
I only want to take for 3 weeks maximum as I have had a bad arthritis...

doctor1 MD

Respected Sir
1. Cortisone (a steroid) is known to increase blood pressure, cause retention of fluid, decrease in blood potassium levels and...

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Hi, My age is 28.. I have mouth ulcers problem,It occurs frequently. From past 6 months its been a part of my routine life.. I am taking...

doctor1 MD

Dear Concerned.,
Thanks for writing to us.,
There are various reasons for mouth ulcers. It could be due to (a) deficiency of B-Complex group of...

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Recent questions on  Cortisone acetate

doctor1 MD

a few years ago, i was forcably kissed by someone (while asleep) and shortly after had an ulcer appear on the lower outside of my mouth. i have had...

doctor1 MD

Can I take cortisone acetate while on blood pressure tablets - karvezide. I only want to take for 3 weeks maximum as I have had a bad arthritis attack

doctor1 MD

I took a fair bit of mdma the last week and since I have develouped several small ulcers on my toung which hurt when they graze my teeth and...

doctor1 MD

Yes concerned about under the inside of my upper lip right where it comes down toward my lower lip was sore around the edge last night felt sore...

doctor1 MD

my husband has been suffering with mouth ulcers and they have also been bleeding very heavy but just today he pulled out this big thing it was full...

doctor1 MD

Hi. I am suffering from very very minor mouth ulceration - mild pain, It comes and goes - not on same location. one of my tooth is also decayed......

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