Comtan

What is Comtan?

Entacapone (INN) ( or ) is a drug that functions as a catechol-O-methyl transferase (COMT) inhibitor. It is used in the treatment of Parkinson's disease.

When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents COMT from metabolizing L-DOPA into 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the periphery, which does not easily cross the blood–brain barrier (BBB). Pharmacologically, entacapone is somewhat similar to carbidopa or benserazide, in that it is an inhibitor of an enzyme that converts L-DOPA into a compound that cannot cross the blood–brain barrier. Carbidopa and benserazide inhibit aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine, which cannot cross the blood–brain barrier.

Entacapone is a member of the class of drugs known as nitrocatechols.

Questions and answers on "Comtan"

HI IS IT SAFE TO BE TAKING COMTAN ALONG WITH IMG OF AXILECT DAILY FOR PARKINSON I TAKE 3SINEMET ALOG WITH ICOMTAN 4 TIMES ADAY AT MYB 10 AM DOSAGE...

doctor1 MD

Brief Answer:
These are routinely used for management

Detailed Answer:
Hi dear.Thanks for giving me an opportunity to address your query.

The drugs...

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I have Parkinson's . On Madopar 300/75 five times a day, Sifrol 3.75 each morning, and Comtan with each dose of levodopa. I am experiencing severe...

doctor1 MD

Hi, Welcome to Health care magic forum.
As you describe, the low blood pressure could be due to the levodopa. It usually, don't cause the hypo...

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My husband aged 68 has had Parkinsons disease for over 11 years. He has been treated with Madopar and comtan and lately tramadol has been added for...

doctor1 MD

Brief Answer:
Next step is probably a sleep study and pulmonary function testing

Detailed Answer:
......would probably be a SLEEP STUDY as well as...

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Recent questions on  Comtan

doctor1 MD

I have early stages of Parkinson s. Tremors in my right hand. I understand exercise is very important. Are there other step I could take to reduce...

doctor1 MD

My husband aged 68 has had Parkinsons disease for over 11 years. He has been treated with Madopar and comtan and lately tramadol has been added for...

doctor1 MD

I have Parkinson s . On Madopar 300/75 five times a day, Sifrol 3.75 each morning, and Comtan with each dose of levodopa. I am experiencing severe...

doctor1 MD

HI IS IT SAFE TO BE TAKING COMTAN ALONG WITH IMG OF AXILECT DAILY FOR PARKINSON I TAKE 3SINEMET ALOG WITH ICOMTAN 4 TIMES ADAY AT MYB 10 AM DOSAGE...

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