What is Clavulanate?
Clavulanic acid (rINN) is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
The drug is marketed by GlaxoSmithKline.
In its most common form, the potassium salt potassium clavulanate is combined with:
- amoxicillin (co-amoxiclav, trade names Augmentin, Tyclav (Beximco), Synulox
[veterinary ], and others) or
- ticarcillin (co-ticarclav, trade name Timentin).
Clavulanic acid is an example of a clavam.