What is Cisapride?

Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.). It was discovered by Janssen Pharmaceutica in 1980. In many countries, it has been either withdrawn from the market or had its indications limited because of side-effects.

The commercial preparations of this drug are the racemic mixture of both enantiomers of the compound. The (+) enantiomer itself has the major pharmacologic effects and does not induce many of the detrimental side-effects of the mixture.

Questions and answers on "Cisapride"

Hi Doctors,
I am suffering from idiopathic constipation and it may spastic colon. With withdrawal of cisapride and tegaserod i am finding it...

doctor1 MD

thank for posting at HCM.

its difficult to figure out the cause of constipation.

- stop any medication being used for constipation for...

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fiber, stool softners q day laxitive every dayy dr say ileus quit started again 3 days later happening for 2 years getting big gut and upset...

doctor1 MD

Brief Answer:
Details below.

Detailed Answer:

Thanks for choosing HealthcareMagic for your query.
As per your query answers are-
As normal...

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dr presribed mydaugher nexium for exessive burping nd acid reflux. on meds 1 month ...nw n hr after taking spitting up something that looks like...

doctor1 MD

Brief Answer:
It can be regurgitant food material

Detailed Answer:

Thanks for asking on this platform

I can understand your concern. Nexium...

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