What is Bumex?

Bumetanide (trade names Bumex or Burinex) is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in people in whom high doses of furosemide are ineffective. It is marketed by Hoffmann-La Roche. The main difference between the two substances is in bioavailability and pharmacodynamic potency. Furosemide is incompletely absorbed in the intestine (60%), and there are substantial inter- and intraindividual differences in bioavailability (range 10-90%). Bumetanide is almost completely absorbed (80%), and the absorption is not altered when it is taken with food. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.

Bumetanide is 40 times more potent than furosemide for patients with normal renal function.

In the brain, bumetanide blocks the NKCC1 cation-chloride co-transporter, and thus decreases internal chloride concentration in neurons. In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, that quite often are not responsive to traditional GABA-targeted treatment, such as barbiturates. Bumetanide is therefore currently under evaluation as a prospective antiepileptic drug.

Questions and answers on "Bumex"

My husband has diabetes mellitus and nephrogenic diabetes insipidus. His doctor had him on Bumex 1 mg, 2 tabs 2 x a day. He was told to take 1 tab...

doctor1 MD

Bumetanide is a potent diuretic that causes a profound increase in urine output by preventing the kidney from retaining fluid. Specifically, it...

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my mother is 88 years old has had syber knife radiation on her brain tumor lung nodules from utirine cancer year and half ago presently in hospitol...

doctor1 MD

Brief Answer:
Keep her under observation.She need Bumex.

Detailed Answer:
Hi Thanks for using XXXXXXX

I can understand your concern and sorry for...

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My dad's nursing home is not able to get Bumex anymore & they are changing him to Lasix. He has kidney failure & is on dialysis. I realize both are...

doctor1 MD

Hi, Welcome to Health care magic forum.
As you describe he is on dialysis, it is for balance of the metabolism,it will make the blood pure so that...

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