Accutane

What is Accutane?

Isotretinoin (INN) (etymology and pronunciation), also known as 13-cis retinoic acid and first marketed as Accutane by Hoffmann-La Roche, is a medication primarily used to treat cystic acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug.

Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2–3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include: muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development.

In the United States a special procedure is required to obtain the pharmaceutical. In most other countries a consent form is required which explains these risks. Women taking isotretinoin must not get pregnant during, and for 1 month after isotretinoin therapy. Sexual abstinence, or effective contraception is mandatory during this period. Barrier methods by themselves (such as condoms) are not considered adequate due to the unacceptable failure rates of approximately 3%. Women who fall pregnant whilst on isotretinoin therapy are generally counselled to have a termination. Isotretinoin has no effect on male reproduction.

In 2009, Roche decided to remove Accutane from the US market after juries had awarded millions of dollars in damages to former Accutane users over inflammatory bowel disease claims. Other common brands are Roaccutane (Hoffman-La Roche, known as Accutane in the United States before July 2009), Amnesteem (Mylan), Claravis (Teva), Absorica (Ranbaxy), Isotroin (Cipla), and Epuris (Cipher).

Questions and answers on "Accutane"

Hi, I have been taking (ro)accutane for just over 6 months now and have never had an issue with it. Recently (about 6 weeks ago) I also started...

doctor1 MD

Hi, Welcome to Health care magic forum.
You was using accutane since 6 months, it has a side effect of hepatic toxicity. more over on long term...

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Hello, in 2004-2005 I took the acne medication, accutane. Recently I found out it was causing bowel problems, my problems came about as minor and...

doctor1 MD

HI
Well come to HCM
I really appreciate your concern, if this was the case of constipation that is having neurological pathology then in such...

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