Wegener's disease

What is Wegener's disease?

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), is a systemic disorder that involves both granulomatosis and polyangiitis. It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs. Damage to the lungs and kidneys can be fatal. It requires long-term immunosuppression. However, the older name is still often seen.

Granulomatosis with polyangiitis is part of a larger group of vasculitic syndromes called systemic vasculitides or necrotizing vasculopathies, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ANCAs (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels. Apart from GPA, this category includes Churg–Strauss syndrome and microscopic polyangiitis. Although GPA affects small- and medium-size vessels, it is formally classified as one of the small vessel vasculitides in the Chapel Hill system.

Questions and answers on "Wegener's disease"

I was diagnosed with Wegeners disease 2 weeks ago after being in remission for about 4 months. They just started
me on Cytoxan which I am to start...

doctor1 MD

hello there!
4 months of remission followed by recurrence shows you were not compliant with cytoxan and steroids and rituxan. Did u take all 4...

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A flu like 8 years ago that nailed me to a bed for 4 days....followed up by vomiting at any movements, follwoed up by tinnitus for ever. Then...

doctor1 MD

No doubt ,you developed influenza 8 years ago .
Now having so many complications and symptoms , may be due to the after effect of that...

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Hi, it all started Around 5 months ago, maybe longer, when I got a pain in my back, rather severe at the time, it hurt like a big giant bruise...

doctor1 MD

Thanks for writing in.
We should be looking at several possibilities given your symptoms. While infection or an autoimmune process is the most...

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