Nephrogenic systemic fibrosis

What is Nephrogenic systemic fibrosis?

Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare and serious syndrome that involves fibrosis of skin, joints, eyes, and internal organs. The first cases were identified in 1997 and its cause is not fully understood. However, evidence suggests NSF is associated with exposure to gadolinium (with gadolinium-based MRI contrast agents being frequently used as contrast agents for magnetic resonance imaging (MRI)) in patients with severe kidney failure. Epidemiological studies suggest that the incidence of NSF is unrelated to gender, race, or age and it is not thought to have a genetic basis. A registry for NSF has identified about 335 cases as of 2011.

Most patients with NSF have undergone hemodialysis for kidney failure, some have never undergone dialysis and others have received only peritoneal dialysis. Many people with NSF have taken immunosuppressive medications and have other diseases, such as hepatitis C. Four of the seven gadolinium contrast agents approved by the U.S. Food and Drug Administration have been principally implicated in NSF, including Omniscan, MultiHance, Magnevist, and OptiMARK.

Questions and answers on "Nephrogenic systemic fibrosis"

Is it safe to have mri/w gad if you have a history of kidney stones?Should I have urological exam before MRI? How often should MRI 'S BE...

doctor1 MD

Brief Answer:
MRI in kidney stone disease

Detailed Answer:
Hi JLR 300,

Kidney stones are not a contraindication for MRI. But we should assess the...

Read Full Thread   Ask a Doctor Now

I developed a rash above my wrist 7-8 hours after I had MRI with dye (omniscan). The area is swollen and feels tight and thickened. The rash is...

doctor1 MD


You seem to have developed an allergic skin disease.
You should avoid applying any kind of skin irritants like dettol, spirit over it.


Read Full Thread   Ask a Doctor Now

my father is being dtected renal stenosis and his creatininine levels is for past 10 been between 1.9 -3.5. Should he be done...

doctor1 MD

Thanks for posting your query.

Your father is having secondary hypertension due to renal artery stenosis. His kidneys are not functioning well...

Read Full Thread   Ask a Doctor Now

Recent questions on Nephrogenic systemic fibrosis

Ask Question
Doctor Image

Hi, I am Dr. Andrew Rynne (Family Physician). I will be guiding you through the process. Please write your question below.

Related Drugs/Medications
Related Medical Topics