Neonatal sepsis

What is Neonatal sepsis?

In common clinical usage, neonatal sepsis specifically refers to the presence in a newborn baby ("neonate") of a bacterial blood stream infection (BSI) (such as meningitis, pneumonia, pyelonephritis, or gastroenteritis) in the setting of fever. Older textbooks may refer to neonatal sepsis as "sepsis neonatorum". Criteria with regards to hemodynamic compromise or respiratory failure are not useful clinically because these symptoms often do not arise in neonates until death is imminent and unpreventable. Neonatal sepsis is divided into two categories: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis presenting in the first 7 days of life (although some refer to EOS as within the first 72 hours of life), with LOS referring to presentation of sepsis after 7 days (or 72 hours, depending on the system used). neonatal sepsis is the single most important cause of neonatal death in hospital as well as community in developing country.

It is difficult to clinically exclude sepsis in newborns less than 90 days old that have fever (defined as a temperature > 38°C (100.4°F). Except in the case of obvious acute viral bronchiolitis, the current practice in newborns less than 30 days old is to perform a complete workup including complete blood count with differential, blood culture, urinalysis, urine culture, and cerebrospinal fluid (CSF) studies and CSF culture, admit the newborn to the hospital, and treat empirically for serious bacterial infection for at least 48 hours until cultures are demonstrated to show no growth. Attempts have been made to see whether it is possible to risk stratify newborns in order to decide if a newborn can be safely monitored at home without treatment despite having a fever. One such attempt is the Rochester criteria.

Questions and answers on "Neonatal sepsis"

My son is 8 years old has been diagnosed with Tonsilitis, his fever shot to 103 F in the first 2 days, however low grade fever - around 100 F has...

doctor1 MD

Thanks for posting your query.
Your son seems to be having a urine infection which could be the cause of persistent low grade fever.

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I am 39 years old and was hospitalized with sepsis from an e coli infection in my blood about a month ago. Drs. said it originated in my kidneys. I...

doctor1 MD

Welcome! I would be pleased to answer your question .

These indicate that there is mild infection present as a few white blood cells bacteria...

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My 16 year old daughter was admitted to hospital with sepsis and septic shock 3 weeks ago. She had gad a course of oral amtibiotics just before she...

doctor1 MD

Thanks for writing in.
Its possible that your daughter is having a drug reaction as she was probably allergic to one of the drugs she was...

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