Hypereosinophilic syndrome

What is Hypereosinophilic syndrome?

The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow.

HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

There are some associations with chronic eosinophilic leukemia as it shows similar characteristics and genetic defects.

If left untreated, HES is progressively fatal. It is treated with glucocorticoids such as prednisone. The addition of the monoclonal antibody mepolizumab may reduce the dose of glucocorticoids.

Questions and answers on "Hypereosinophilic syndrome"

my brother in law has hypoeosinophilitis syndrome and has had two hip replacements in the past two years. I noticed he does not take very good care...

doctor1 MD

Brief Answer:
Advise him to Quit Alcohol.Health check regularly.

Detailed Answer:
Hello,
Welcome to XXXXXXX

Symptoms in Hypereosinophilic syndrome...

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My 11 year old son who has Eoe has had a blood test showed Vitamin B12 was high. It went from 1313 to 1346. All of his liver and regular CBC came...

doctor1 MD

Brief Answer:
Eosinophilic esophagitis is the probable cause of high vitamin B 12

Detailed Answer:
Hello,
Thanks for positing your query on...

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I am suffering from very high AEC count in blood. I am facing problem of breath shortening and Gastric Problems for last 6 years but I kept...

doctor1 MD

Hello and welcome to HCM,
AEC count is the absolute eosinophil count.
The normal AEC is between 100-600/ cobic millimeter.
Eosinophil count...

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