Follicular lymphoma

What is Follicular lymphoma?

Formally designated as follicle center cell lymphoma with follicular growth it is a common subtype of non-Hodgkin lymphoma; of B-cell origin, they may consist of primarily small-cleaved cells, large cells, or a mixture of the two types. Most follicular lymphomas have a t(14;18) gene translocation resulting in a rearranged and constitutively overexpressed gene called BCL-2 that acts as an antiapoptotic oncogene. These tumors are generally not curable but have a prolonged natural history. Characteristic immunophenotype of these cells is CD10 positivity, in addition to B-cell–associated antigens CD19 and CD20.

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My sister has stage IV Follicular Lymphoma (B Cell Complex). Her spleen has been removed and nodes in her neck are also affected, She is 46 and...

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