Cyclical neutropenia

What is Cyclical neutropenia?

Cyclic neutropenia (or cyclical neutropenia) is a form of neutropenia that tends to occur every three weeks and lasting three to six days at a time due to changing rates of cell production by the bone marrow.

Cyclic neutropenia is a rare condition and is estimated to occur in 1 in 1 million individuals worldwide. Treatment includes G-CSF and usually improves after puberty.

Cyclic neutropenia is the result of autosomal dominantly inherited mutations in ELA2, the gene encoding neutrophil elastase.

Questions and answers on "Cyclical neutropenia"

i suffer from a condition known as cyclical neutropenia. I have been dealing with blood draws and been treated by hematologists my entire adult...

doctor1 MD

Hello and thank you for sending your question.

Your question is a very good one and I will work on providing you with some information and...

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My 4 year old daughter has low neutrophil count which in the range of 100 - 1000 and changes from week to week. Sick kids has completed a smear...

doctor1 MD

Thanks for your query. I understand your concern. If neutrophils are the only problem and plat and hemoglobin are fine, then cyclic neutropenia...

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actually i m suffering from mouth ulcer in inner area since long (about 3 yrs). It happens very frquently like every 15-20 days.. I get again..I...

doctor1 MD


If it is regularly intermittent it could be cyclical neutropenia. Kindly get a CBC (Complete Blood Count) done when you have the problem....

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