Cholestatic liver disease

What is Cholestatic liver disease?

The condition known by its abbreviation PBC, standing for primary biliary cirrhosis, is an autoimmune disease of the liver. It is marked by slow progressive destruction of the small bile ducts of the liver, with the intralobular ducts (Canals of Hering) affected early in the disease. When these ducts are damaged, bile and other toxins build up in the liver (cholestasis) and over time damages the liver tissue in combination with ongoing immune related damage. This can lead to scarring, fibrosis and cirrhosis. As cirrhosis is only a feature of advanced disease, a change of name to primary biliary cholangitis was proposed in 2014. This retains the initials of PBC but reflects more accurately the nature of the disease. It has not yet (April 2015) been adopted in scientific publications.

PBC was previously thought to be a rare disease, but more recent studies have shown that it may affect up to 1 in 3–4,000 people; the sex ratio is at least 9:1 female to male.

Questions and answers on "Cholestatic liver disease"

i have crirrocis quit drihking 2years but i have bad itching

doctor1 MD

Brief Answer:

Detailed Answer:
Hello and welcome,

I am really sorry about the itching related to your liver.

Here are some things you...

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I am wondering if I should have a diagnosis of cholestatic liver disease . I have finally found a diagnosis that covers all of my sypmtoms but I am...

doctor1 MD

Thanks for writing in to us.

Nonalcoholic fatty liver disease is a term used to describe the accumulation of fat in the liver of people who...

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could you tell me a womans normal gamma gt reading please

doctor1 MD

Thanks for the query.

Gamma-glutamyl transferase(GGT) is normally between 0-51IU/L in women, although the normal range could vary slightly from...

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