Castleman's disease

What is Castleman's disease?

Castleman disease, also known as giant or angiofollicular lymph node hyperplasia, lymphoid hamartoma, angiofollicular lymph node hyperplasia, is a group of uncommon lymphoproliferative disorders that share common lymph node histological features that may be localized to a single lymph node (unicentric) or occur systemically (multicentric). It is named after Benjamin Castleman.

Multicentric Castleman disease (MCD) involves hyperactivation of the immune system, excessive release of proinflammatory chemicals (cytokines), proliferation of immune cells (B cells and T cells), and multiple organ system dysfunction. Castleman disease must be distinguished from other disorders that can demonstrate "Castleman-like" lymph node features, including reactive lymph node hyperplasia, autoimmune disorders, and malignancies. While not officially considered a cancer, the overgrowth of lymphocytes with this disease is similar to lymphoma and more research is needed to search for small populations of neoplastic cells. Castleman disease is a focus of intense ongoing research.

Questions and answers on "Castleman's disease"

hi and thanks my 26 year old daughter was diagn with castlemans disease . she has an enlarged lympnode on her neck which they did a biopsy the...

doctor1 MD

FDG (the medicine used in PET scan) uptake in castleman disease is modest. No large scale studies have established the role of PET-CT in castleman...

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Carcinoid Syndrome extremely elevated chrom a and serotonin :

Hi I am a 37 year old female. I was diagnosed 13 years ago with...

doctor1 MD


Thanks for writing in.

The symptoms are classical of neuroendocrine tumor (carcinoid). On the top of that a high chromogranin and serotonin...

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