D-dimer

What is D-dimer?

A dimer byproduct resulting from fibrinolysis; produced by cross linkage of d-domain fibrin monomers by activated factor XIII, fibrin stabilizing factor; present in low levels in normal animals, but found at particularly high levels in association with thrombotic and hemostatic disorders; assayed as an adjunctive diagnostic tool in conditions such as malignant neoplasia, infectious disease, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, hyperadrenocorticism, pulmonary thromboembolism, and disseminated intravascular coagulation or DIC. d-dimer production requires both plasmin and thrombin activation. Note that generation of fibrin/fibrinogen degradation products (FDPs) requires only plasmin action on fibrin or fibrinogen. d-dimers clear through urinary excretion, so assay may show falsely increased levels during renal dysfunction. Laboratory ELISA measurement can identify fibrinolysis.

Questions and answers on "D-dimer"

I am 57 years old, am 5'6", and 140 lbs. Due to arthritis, I'm taking NSAIDS. Yesterday, I noticed a bruise on the back of my forearm, with a lump...

doctor1 MD

Hello,

Thanks for posting your query.

A bruise happens because of trauma when blood from the ruptured capillaries (small blood vessels)near the...

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I have small pinhead water blisters on both sides of the Achilles tendon and along the sides of my foot. After sitting and then upon rising, there...

doctor1 MD

Hello,
Thanks for posting your query.
From the description given it seems that you are having some ischemic changes in your leg. The second most...

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I was just woken up by pain XXXXXXX in my right leg. I am a skier when it is ski season and it doesnt feel muscular. I was just diagnosed with...

doctor1 MD

Hi! XXXXXXX

The pain may be due to XXXXXXX VEIN THROMBOSIS (DVT).

DVT is the formation of a blood clot ("thrombus") in a XXXXXXX vein. XXXXXXX...

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