I assume from your question that you are currently pregnant again. given a history of preeclampsia, two PEs, a previous abruption and the rest, you are clearly at significant risk for pregnancy complications. it is almost certain that you have a disorder of hypercoagulability, and factor V Leiden is such a disorder. the truth is, that regardless of whether or not you also have MTHFR probably won t make that much of a clinical difference, as you need to be treated aggressively anyway. I assume that your doctor will discuss with you treatment with lovenox or with heparin throughout your pregnancy. if not, you definitely need to discuss this with him/her. although you will probably be treated the same either way, I think that you should be tested for MTFHR as well, if you haven t been already. discuss that with your doctor and find out why he/she doesn t want to test you for this, maybe I am missing something. I hope this is helpful, good luck on the pregnancy!