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Old Aged, Takes Antihypertensive, PSA Increases Often, CT Shows Prostate Cancer Enlarged. When To Start Taking Abiraterone?
84 yrs old. Otherwise good health. Takes antihypertensive. PSA increases every 2 mos by 20 points for last 3-4 readings. Has HRPC. On Prednisone 5 mg BID. CT shows prostate cancer has enlarged and in a lymph node adjacent prostate. Bone scan normal. CXR normal. There seems to be the view that it is better to just use Prednisone until PSA doubles in 2 mos time. When to start taking Abiraterone?
Mon, 7 Oct 2013
User's Response
HI
Thank for asking To HCM
HRPC (Harmon refractory Prostrate Cancer) In case of symptomatic HRPC Chemotherapy gives good result with minimal toxicity, again Aberaterone is specific enzyme inhibitory drug only given when anti-androgen fails to respond, but i think as such we do not have any authentic proof which proves that Prednisone is not responding,, you said that PSA is increasing but this not the gold criteria to prove the treatment failure, the combination therapy would give good result ( Chemotherapy+ Steroid) that is Taxotere+Prednisone, discus it with onco-physician, if your father is asymptomatic then I would suggest you to keep only steroid therapy, take care of your father, bye
Thank for asking To HCM
HRPC (Harmon refractory Prostrate Cancer) In case of symptomatic HRPC Chemotherapy gives good result with minimal toxicity, again Aberaterone is specific enzyme inhibitory drug only given when anti-androgen fails to respond, but i think as such we do not have any authentic proof which proves that Prednisone is not responding,, you said that PSA is increasing but this not the gold criteria to prove the treatment failure, the combination therapy would give good result ( Chemotherapy+ Steroid) that is Taxotere+Prednisone, discus it with onco-physician, if your father is asymptomatic then I would suggest you to keep only steroid therapy, take care of your father, bye
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