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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Would Discontinuing Duphaston During A Possible Pregnancy Lead To A Miscarriage?

Hi. Does stopping intake of duphaston possible pregnancy causes miscarriage.? I was diagnosed with pcos and my gynac prescribed me to take clomid and then hcg injection .after that i was put on duphaston 10 mg twice a day.but i stopped taking duphaston from 25 day of my cycle and i noticed bleeding today ie. 329 day of my cycle. I want to know whether it is a miscarriage or i was not pregnant. Please help me what to do now Thank you
Wed, 16 Jan 2019
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General & Family Physician 's  Response
Hi,

Clomid and HCG injections prescribed would have helped your ovaries in the process of maturation and release of ovum. Duphaston tablet is a synthetic progestogen 'Dydrogesterone'. It has a similar action to the female hormone, progesterone.

Following fertilization, progesterone is the hormone which would help in the process of implantation and continuing with the pregnancy.

Since its production is subnormal in cases of PCOS, its supplementation externally would be essential. Its supplementation would help to reduce the risk of miscarriages or abortions.

That was the reason why your doctor had prescribed to take, as, if at all you had conceived, it would have helped in continuing with the pregnancy.

Since you have stopped it prematurely, it might have caused breakthrough bleeding.

It would be difficult to say as to whether you had conceived or not, as that could have only been confirmed by your blood beta-hCG levels and ultrasound scan at a later date.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Ashakiran S, General & Family Physician
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Would Discontinuing Duphaston During A Possible Pregnancy Lead To A Miscarriage?

Hi, Clomid and HCG injections prescribed would have helped your ovaries in the process of maturation and release of ovum. Duphaston tablet is a synthetic progestogen Dydrogesterone . It has a similar action to the female hormone, progesterone. Following fertilization, progesterone is the hormone which would help in the process of implantation and continuing with the pregnancy. Since its production is subnormal in cases of PCOS, its supplementation externally would be essential. Its supplementation would help to reduce the risk of miscarriages or abortions. That was the reason why your doctor had prescribed to take, as, if at all you had conceived, it would have helped in continuing with the pregnancy. Since you have stopped it prematurely, it might have caused breakthrough bleeding. It would be difficult to say as to whether you had conceived or not, as that could have only been confirmed by your blood beta-hCG levels and ultrasound scan at a later date. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Ashakiran S, General & Family Physician