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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Why would a doctor administer a beta blocker like Sotalol for gall bladder disease ?

Why would a doctor administer a beta blocker like sotalol to a pt who has gallbladder disease? what is the doctor's goal with using sotalol? also, what is MOA (mechanism of action)/the physiology behind the Sotalol's being able to treat gallbladder disease?
Mon, 27 Apr 2015
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General & Family Physician 's  Response
Hi, I had gone through your question and understand your concerns.


Sotalol is indeed a beta blocker.
Sotalol non-selectively binds to both β1- and β2-adrenergic receptors preventing activation of the receptors by their stimulatory ligand. Without the binding of this ligand to the receptor, the G-protein complex associated with the receptor cannot activate production of cyclic AMP, which is responsible for turning on calcium inflow channels. A decrease in activation of calcium channels will therefore result in a decrease in intracellular calcium. In cardiac cells, calcium is important in generating electrical signals for contraction, as well as generating force for contraction.


It has no action in the biliary tree.

Your doctor must have prescribed it due to some comorbidities like ischaemic heart disease or inflammatory pathology of heart called cardiomyopathy.

It is not used directly for the gall bladder disease but it must be used in the patient on the basis of the comorbidity , he/she must be having.


Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions.
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