Hi, I have recently started taking spironolactone for adult acne. I started at 50 mg once daily in the morning, but now am at 50 mg 2X daily, morning and night. I also take vyvanse daily for my ADHD. I have noticed a decrease of effectiveness of my vyvanse since starting Spiro, and after some research discovered that it was due to the diuretic effect of Spiro. I have to take my vyvanse in the morning, so I was wondering if there was a time i could take spiro to get optimal results without interacting with my other medication? Thank you.