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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What would very high ALT and AST levels in a breast cancer patient indicate?

I just returned from a 6 month follow up appt with my Oncologist (6 yrs post treatment for Stage II triple negative breast cancer). Blood test showed elevated levels of ALT (50 U/L) and AST (42 U/L). My last six visits showed the following levels: Prior ALT: 18     18     21     27     29     27 Prior AST: 16     21     18     16     17     16 The numbers are more than double. Does this look like fatty liver and could chemo/radiation treatments have had an impact on my liver?
Tue, 12 Feb 2019
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General & Family Physician 's  Response

I understand your concern.

Your increased liver enzymes levels can indicate possible fatty liver. However, confirmatory tests are further suggested including abdominal ultrasound; lipid profile testing and complete blood count; hepatitis testing (HbsAg, anti-HCV)

Your chemotherapy has been carried out 6 years ago, could be also another cause but we want to exclude other factors first.

Discuss this further with your doctor.
All the best and God bless.
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