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Dr. Andrew Rynne

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Exp 50 years

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What would be a good supplement along with the Addreall for dopa-mine ?

I currently taking Adderall 12.5 mg daily. I ve read that it can lower the amount of dopamine stored in the brain . I also read that L-TYROSINE is the pre cursor to dopamine and taking a L-tyrosine supplement can help maintain normal levels. Would it be a good idea to take such a supplement along with the Addreall?
Fri, 6 May 2011
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Psychiatrist 's  Response
Adderall acts by increasing the availability of dopamine in the brain synapses (areas where neurons interact). This is done by releasing dopamine stored in the brain neurons. Long term use can deplete brain dopamine.

L-tyrosine is a dopamine precursor that is synthesised by the body in sufficient quantities. One of the actions of Adderall is to reduce tyrosine hydroxylase activity in the brain. This is a key enzyme to convert tyrosine into dopamine. The available tyrosine cannot be converted to dopamine. The availability of tyrosine is not an issue with Adderall use. Also, studies have not indicated any long term benefit for the use of L-tyrosine in the treatment of individuals with ADHD.

Hence taking an L-tyrosine supplement along with Adderall would not be the answer to prevention/treatment of dopamine depletion in the brain. If you really feel you must; then consider natural food sources of tyrosine - fish, soy products, poultry, eggs, dairy products, lima beans, almonds, peanuts, sesame seeds, pumpkin seeds, wheat germ, oats, avocados, and bananas.

However, the bottom line remains regular follow-up with your prescribing doctor. It is during these sessions that side effects,including those resulting from dopamine depletion, are monitored and addressed.
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OBGYN Dr. Rakhi Tayal's  Response
Thanks for choosing HealthcareMagic forum.
What you have read is correct and there might be slight lowering in the levels of dopamine. L-tyrosine will definitely help in formation of higher amounts of dopamine in your body but how much of it will reach the brain after crossing the blood brain barrier is doubtful.
Dr. Rakhi Tayal
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