Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
152 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction

What should be the gap between intake of methadone and buprenorphine?

Hi, I am taking 30 mg. of methadone a day. I am thinking about changing to buprenorphine. How long do I have to wait since my last dose of methadone 30 mg. before I can take buprenorphine. I am opiate dependant. I am wanting to get off of pills all together.
Thu, 25 Apr 2019
Report Abuse
Question is related to
Drug/Medication ,   ,  
Treatment/Therapy
Internal Medicine Specialist 's  Response
Hello,

The half-life of Methadone in an opioid-tolerant patient is approximately 24 hours. Its half-life ( t1/2 ) in an opioid-naive patient is approximately 55 hours. Therefore, the duration of effect is extended in opioid-naive patients.

The t1/2 of Buprenorphine is 37 hrs. Both are narcotic analgesic and switch over should be under supervision of a physician or psychiatrist because of drug dependence and consequent withdrawal symptoms.

Hope I have answered your query. Let me know if I can assist you further.

Thank you.

Regards,
Dr. Tushar Kanti Biswas
Internal Medicine Specialist
I find this answer helpful
Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]
Share on
 

Related questions you may be interested in

doctor1 MD

buprenorphine is a drug prescribed to me but I read that if I have problems such as --- asthma - urinary - diabetes - sleep apnea- etc. other...

Recent questions on  Drug rehabilitation

doctor1 MD

Dear Doctor, My Daughter who is aged 18 years has an aso levels of 600 and she has been prescribed Penidure 12 La, when we approached a physician...

doctor1 MD

I suffer from chronic pain in the pekvis I have a neurstimulator implanted and take 10 mg methadone a day to control pain. My Dr has suggested I...

doctor1 MD

I have been off Zoloft since January 2012, I went through major withdrawal from it that last about 6 months by the time I started to get back to...

doctor1 MD

drug addiction My other half has used heroin before about a year ago the wanted to quit so used methadone pills illeagally to try and quit by...

doctor1 MD

If I am addicted to opiates, will tramadol keep me from going into withdrawal and being "dope sick?"

doctor1 MD

I have joint pain and use hydocodone - 10 milliigrams each day only and tramadol , only because it was prescribed in 1985 and probably withdrawal...

doctor1 MD

I had three beers from 8-10 and at about 11:15 I completely forgot I had been drinking and took 5mg of ambien becuase i have been having major...