What should be the gap between intake of methadone and buprenorphine?
Hi, I am taking 30 mg. of methadone a day. I am thinking about changing to buprenorphine. How long do I have to wait since my last dose of methadone 30 mg. before I can take buprenorphine. I am opiate dependant. I am wanting to get off of pills all together.
The half-life of Methadone in an opioid-tolerant patient is approximately 24 hours. Its half-life ( t1/2 ) in an opioid-naive patient is approximately 55 hours. Therefore, the duration of effect is extended in opioid-naive patients.