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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is The Treatment For Recurring Hepatitis B?

Hello Doctor, I am really scared being sick ! My family practice said my hepatitis B virus come back, after 5 year being cured, already treated well, my blood result , Hepatitis B Core Antibody (IGM) is Non-Reactive, Hepatitis B Core AB Total is Reactive, Hepatitis B Surface Antigen (REFL) is reactive. I Have been treated well with Baraclude entecavier for 15 months, the Doctor said I already have, antibody again hepatitis B, I am 51 years, female with 117 lbs and 5 feet 1, My Hepatitis B virus DNA currently result units 9909 IU/ml My Hepatitis B virus DNA currently result 3.99 LogIU/ml Doctor can you please explain, why my hepatitis B come back, after 5 years, I am really give up, Thanks and Besat Regard, Theresa Teng
Mon, 27 Apr 2015
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General & Family Physician,  's  Response
Hi, I had gone through your question and understand your concerns.

Let me analyse your reports-

1.HBsAg - reactive (HBsAg is a marker of both acute and chronic HepB infection)
2.IgM antiHBc - nonreactive , IgG antiHBc - reactive ( IgM antiHbc is a marker of acute infection , IgG is a marker of chronic infection)
3. HBV DNA copies are nearly 10^4 .

This actually points towards recurrence of chronic hepatitis B.

Serum HBsAg level at the end of treatment and rate of HBV DNA suppression can provide supplementary information to guide the timing of stopping anti-viral drugs.To prevent relapse in patients with chronic hepatitis B infection , age and serum bilirubin level of patients as well as a prolonged duration of additional therapy should be considered.

There are plenty of medications available as you know like Entecavir , Pegylated Interferon and others. They can be started based on the HBV DNA level and SGOT,SGPT level.

Do not worry.

It would have been great had I examined him on my own.
I would suggest you to take him to a gastro-enterologist . He/she can examine him and correlate clinically.

Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions.

Wishing your good health.
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What Is The Treatment For Recurring Hepatitis B?

Hi, I had gone through your question and understand your concerns. Let me analyse your reports- 1.HBsAg - reactive (HBsAg is a marker of both acute and chronic HepB infection) 2.IgM antiHBc - nonreactive , IgG antiHBc - reactive ( IgM antiHbc is a marker of acute infection , IgG is a marker of chronic infection) 3. HBV DNA copies are nearly 10^4 . This actually points towards recurrence of chronic hepatitis B. Serum HBsAg level at the end of treatment and rate of HBV DNA suppression can provide supplementary information to guide the timing of stopping anti-viral drugs.To prevent relapse in patients with chronic hepatitis B infection , age and serum bilirubin level of patients as well as a prolonged duration of additional therapy should be considered. There are plenty of medications available as you know like Entecavir , Pegylated Interferon and others. They can be started based on the HBV DNA level and SGOT,SGPT level. Do not worry. It would have been great had I examined him on my own. I would suggest you to take him to a gastro-enterologist . He/she can examine him and correlate clinically. Hope this answers your question. If you have additional questions or follow up questions then please do not hesitate in writing to us. I will be happy to answer your questions. Wishing your good health.