In the last six months I ve had two fusion surgeries done. One at my C3-C4 and one at my L5-S1. I came out of the neck fusion fine, textbook recovery and doing well. However, with my back surgery I developed a really bad reaction to the surgical glue they used to glue the steri-strips (sp?) to hold my incision together. After a medrol dose pack I was fine, and felt very well at about 2-3 weeks post op. Then suddenly at about 4 weeks I developed a really bad itching with swelling in my hands and feet as well as huge hives, small welts and patches of rash all over my arms, neck, chest, tops of my feet, on my face and in my ears. At one point I ended up with a swelling and burning feeling on the left side of my tongue and left tonsil. My hands and feet would end up being painful in all the joints at the worst flare ups . I ended up going to the ER three times for various problems with this reaction and was told to take benadryl. After followup with my primary care he put me on hydroxyzine and another medrol dose pack. After finishing the dose pack I did really well for about 3-4 days and even got to where I didn t have to take anything for itching/hives. But then the rashes, itching and hives have slowly come back and gotten worse, I m now on another medrol dose pak and taking the hydroxyzine every 4-6 hours. Originally my surgeon s PA thought it was a reaction to the Norco and Robaxin I was on post surgery so I ve been off of that for about 3 weeks or so. My primary care doctor believes this is a an over reaction my body is having due to the trauma of having two major surgeries within a 6 month time period. My questions are: Is this possible? And if so, why does it happen and how long can it last? When should I be worried that something else is going on with my body? I don t have a history of allergies except a reaction to penicillin when I was about 8 years old. I ve never even had seasonal allergy issues so I m really at a loss as to what I can do.