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What is the purpose of down syndrome test in pregnancy ?

Down syndrome test purpose? Femlae age-36 Down syndrome results age-1/262 bio.21-1/251 AFP 1U/mL :23.0 0.792 MOM free BhCG ng/mL :26.0 1.256 MOM uE3 ng/mL : 2.0 0.405 MOM
Asked On : Tue, 29 Mar 2011
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Infertility Specialist 's  Response
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Approximately 2% of births are associated with congenital abnormalities .The most common chromosomal abnormality is Down’s Syndrome. Downs syndrome babies have multiple inherited defects including intellectual disability, bowel and heart abnormalities and risk of leukemia. The risk of having baby with Downs syndrome is higher with maternal age. For example, at age 35 the risk of having Downs Syndrome baby is 1 in 400 . Hence, the Triple Test a blood test used as a primary screening tool to assess the chance of the pregnancy being affected by Down’s syndrome. The results from all of the biochemical tests are used together to estimate the possibility of a Down’s syndrome affected baby. Maternal blood is taken for measurement of AFP, b-HCG, and unconjugated oestriol. In some centres, pregnancy associated plasma Protein (PAPPA) and inhibin A are also measured. In reality, due to large variation in Triple Test results due to influence from many factors, biochemical risk is calculated and adjusted for maternal age and weight to calculate the chance of the baby being affected by Down’s syndrome. Take care.
Answered: Sat, 16 Jul 2011
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