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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is The Problem In Getting Pregnant?

We have been TTC for last 2 years. My periods became irregular around 1.5 year back. We consulted a doctor and she found that I didn\'t ovulate normally. All other tests including blood, tube patency , ultra sound reported everything as normal. My husbands sperm count too was normal ( Vol. 3Ml, Count 90Mn/ml , Active -50%, sluggish -20,dead -30 , MOrphology - 75% normal, Ph-8.5) I am taking Glyciphase SR 500Mg(1-0-1) and Ebexid along with FA regularly. Then she put me on Clomoid 100 MG for 6 Months and then to Letroz 2.5 for the last two cycles. Though follicular study shows ovulation , I haven\'t conceived yet. She is trying Letroz for this month too If you could clarify some of my doubts , it would be a great relief 1. Prior to Clomoid induction, I haven\'t experienced any sort of Ovulation discomfort. Does that mean that I was not at all ovulating 2. My follicular study during previous cycle shows 10*8 on 13 DPO and on 15 I experienced Ovulation pain. Scan on 16 DPO confirmed ovulation. Will the egg be normal while considering the sudden growth? 3. Even after life style change and ovulation induction drugs, my cycles are not returned to the 28 day. The ovulation occurs normally on 18 th day ( except last) and my average cycle length is 33-32 days. Does it shows any sort of drug resistance? Does the egg released on 18th has any drawback while compared to the one relased on 14? We are quite frustrated , Please would you enlighten us with your suggestions
Mon, 21 Dec 2015
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OBGYN 's  Response
Hi there,
Welcome to HCM,
You have already tried 6 months of Clomid and 3 months of Letroze without success, and all other parameters are normal. I would advise you to consider ovulation induction using Gonadotropins followed by IUI or IVF.
Usually Clomiphene is advised only for 6 months, if it doesn't work in 6 months its unlikely to give results. Letrozole is not recommended any more for ovulation induction.
I would advise you to consider IVF, it will give you better success rates.
Hope this helps.
Regards.
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What Is The Problem In Getting Pregnant?

Hi there, Welcome to HCM, You have already tried 6 months of Clomid and 3 months of Letroze without success, and all other parameters are normal. I would advise you to consider ovulation induction using Gonadotropins followed by IUI or IVF. Usually Clomiphene is advised only for 6 months, if it doesn t work in 6 months its unlikely to give results. Letrozole is not recommended any more for ovulation induction. I would advise you to consider IVF, it will give you better success rates. Hope this helps. Regards.