- Generic name is Lisinipril. It is an Angiotensin
converting enzyme (ACE) inhibitor. It reduces the synthesis of aldosterone
by blocking the conversion of angiotensin-1 to angiotensin-2. This lowers BP. Both systolic & diastolic BP is reduced. It is the drug of choice in diabetic hypertensives. It also enhances sodium excretion. Though hyponatremia
(low sodium level) is a potential side effect of Prinivil it does not occur very freequently. The upper limit of salt intake in hypertensives as per the Dietary Guidelines of Americans is 1500mg/day.
Sodium level of 133mEq/lit does not signify hyponatremia (normal-136-145mEq/lit) though fatig ue,headahe are the symptoms of hyponatremia. Palpitations, headache & fatigue
can occur due to hypotension( rapid fall in BP) which is quite common in the initial phases of therapy.