Hello, Thank you for contacting HCM I understand your concern, I am Dr Arun Tank, Infectious Disease Specialist answering your query. C1 esterase is the enzyme present in our body which prevents the cascade of complement system. This system is also a part of the immune system. But to control this system C1 esterase is essential. As you are deficient for this enzyme there is likely to cause exaggerated response of complement system. The symptoms is angioedema means swelling around neck and face. which may cause chocking. It is mostly a genetic one not a acquired one. Hypertension and weight loss in not associated with this deficiency but it may be associated with some syndrome. I advice you to visit nearby multispeciality hospital and get your complete physical examination done this will give you idea reagrding the syndrome you have. You can ask for further queries here on bit.ly/DrArun. Thank you, Dr Arun Tank Infectious Disease specialist We wish you a best health at health care magic.