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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Is Stiff Person Syndrome?

Hi, may I answer your health queries right now ? Please type your query here...I have been diagnosed with Stiff Person Syndrome and the doctor says my GAD levels are very high at 2,200. Can you explain this to me? I'm 64 and 5'4" and weigh 140 lbs. I do not have diabetes.
Mon, 2 Feb 2015
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Pathologist and Microbiologist 's  Response
Hi
Thanks for your query
Based on your query, my opinion is as follows
1. Stiff person syndrome is a progressive disorder of motor neurons, characterized by muscle stiffness/ painful spasms of spine and lower limbs.
2. It is autoimmune in origin with presence of GAD antibodies.
3. GAD antibodies are glutamic acid antibodies, which act against the nerve terminals in central nervous system and against beta cells of pancreas.
4. Presence of these antibodies in CSF correlates with CNS symptoms and the disease progression
5. Beta cells are the site of insulin production, when targeted makes an individual prone for type 1 diabetes mellitus. So there is a risk of having diabetes with the present levels in your case.
Hope this helps
Regards
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What Is Stiff Person Syndrome?

Hi Thanks for your query Based on your query, my opinion is as follows 1. Stiff person syndrome is a progressive disorder of motor neurons, characterized by muscle stiffness/ painful spasms of spine and lower limbs. 2. It is autoimmune in origin with presence of GAD antibodies. 3. GAD antibodies are glutamic acid antibodies, which act against the nerve terminals in central nervous system and against beta cells of pancreas. 4. Presence of these antibodies in CSF correlates with CNS symptoms and the disease progression 5. Beta cells are the site of insulin production, when targeted makes an individual prone for type 1 diabetes mellitus. So there is a risk of having diabetes with the present levels in your case. Hope this helps Regards