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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What effect will this have on the release of TSH?

The hormone thyroxine is released in response to a pituitary hormone called thyroid stimulating hormone(TSH). As thyroxine levels increase in the blood, they exert negative feedback on the release of TSH by the pituitary gland. What effect will this have on the release of TSH?
Thu, 19 Jan 2017
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Endocrinologist 's  Response
Hello,

I have gone carefully through your concern. Hypotalamo-pituitary-thyroid axis works through a negative feed back mechanism. It means that when the thyroid hormones are high, the hypotalamus and pituitary hormones (TRH and TSH respectively) are inhibited so that the thyroid won't be stimulated further. That is why TSH is always low in hyperthyroidism or over active thyroid. The contrary happens in hypothyroidism.

Hope the information will help. Let me know if I can assist you further.

Kind regards,
Dr. Mirjeta
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What effect will this have on the release of TSH?

Hello, I have gone carefully through your concern. Hypotalamo-pituitary-thyroid axis works through a negative feed back mechanism. It means that when the thyroid hormones are high, the hypotalamus and pituitary hormones (TRH and TSH respectively) are inhibited so that the thyroid won t be stimulated further. That is why TSH is always low in hyperthyroidism or over active thyroid. The contrary happens in hypothyroidism. Hope the information will help. Let me know if I can assist you further. Kind regards, Dr. Mirjeta