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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does This Beta Thalassemia DNA Genetics Indicate?

Hi doctor I have Beta Thalassemia Plus Trait (AT+) and want to marry a man with Sickle Trait (AS). Besides my blood group is O+ and my partner is A+. We both does not have G6 PD.My father has beta sickle thalassemia plus but he lives normal life and never requires any blood transfusion at all. My mother does not has beta thalassemia or sickle trait. Please see the attached file of my Beta Thalassemia DNA genitics. Please give me the possibilities of our baby if we got married. Of course 25% our baby may have Sickle Beta Plus Thalassemia (ST +) because my DNA beta Thalassemia gene is plus as the given report shows. Will the symptoms severe or mild or consider him as carrier with very slight symptoms that it will not require blood transfusion at all. What is your recommendations doctor. We love each other and want to be sure about our baby in the future if we got married. I should be grateful if u give me more details of symptoms of the coming baby if he got Sickle Beta Plus Thalassemia (ST +).According to given attached report.which symptoms the baby may has in his life generally. Will his life like normal one. Give examples please. And our marriage will be safe or not for our coming kids. I am looking forward to your reply Thanks doctor.
Tue, 31 Jul 2018
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Pediatrician 's  Response
Hello and Welcome to Ask A Doctor. I have reviewed your query and here is my advice.

If one parent has beta thalassemia trait and the other has sickle cell trait, there is a:
-25% chance with each pregnancy of having a baby with beta thalassemia trait (no symptoms or only mild anemia)
-25% chance with each pregnancy of having a baby with sickle cell trait (usually no symptoms or mild anemia)
-25% chance with each pregnancy of having a baby with sickle cell disease (pain in bone or small blood vessels, susceptible to infections)
-25% chance with each pregnancy of having a baby with trait or disease.

I was not able to locate the report.

Hope I have answered your query. If you have any further questions, I will be happy to help.

Arnold Zedd, MD, FAAP
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What Does This Beta Thalassemia DNA Genetics Indicate?

Hello and Welcome to Ask A Doctor. I have reviewed your query and here is my advice. If one parent has beta thalassemia trait and the other has sickle cell trait, there is a: -25% chance with each pregnancy of having a baby with beta thalassemia trait (no symptoms or only mild anemia) -25% chance with each pregnancy of having a baby with sickle cell trait (usually no symptoms or mild anemia) -25% chance with each pregnancy of having a baby with sickle cell disease (pain in bone or small blood vessels, susceptible to infections) -25% chance with each pregnancy of having a baby with trait or disease. I was not able to locate the report. Hope I have answered your query. If you have any further questions, I will be happy to help. Arnold Zedd, MD, FAAP