Hello and Welcome to Ask A Doctor service. I have reviewed your query and here is my advice. As per your complain pain in toenail on big toe can be due to Ingrown Toenail. Ingrown toenail is a condition in which there is overgrowth of the toenails edges towards the soft skin inwards leading to inflammation and severe pain and swelling in the area. It is generally seen in individuals with bigger toenails as well as it can also occur if you wear tight shoes or you do not trim the nails properly. You might been advised creams with combination of medications like antibiotic and antifungal creams along with steroid cream to relieve pain and swelling. You should soak your feet in warm water and when the nail ad skin become soft gently raise the nail at the corners outwards and trim gently. It will prevent nail from growing inwards. You can also wear proper fitting shoes. Trim your nails as soon as they grow sufficiently and do not let them grow very long. You can also soak your feet in Epson salt solution. At times in cases in which the medical or conservative treatment fails you can be advised to go for surgical treatment like Matrixectomy. Hope I have answered your query. Let me know if I can assist you further.