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Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What does normal karyotype with decrease in length of heterochromatin region mean?

Iam amutha,during my first prenancy,in 6th month I terminated my baby due to abnormalities. then u consulted a genetician ,they said to take karyotype chromosome blood test.

the result of cytogenetic report showed karyotype-46,xy,1qh-,15ps+.

Interpretation- Normal Karyotype with decrease in the length of heterochromatin region on the long arm of chromosome 1 and increase in the length of satellite on the short arm of chromosome 15(normal variant) for my husband and normal for me.

If there is any problem in my next pregnancy.We want to take any treatment,Please we need your suggestion.
Fri, 9 Jan 2015
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Pathologist and Microbiologist 's  Response
Hello and welcome to HCM,
The karyotype report shows a normal variation in the structure of the chromosome number 1 and 15.
The most common chromosomal abnormalities which are responsible for firts trimester abortions are structural abnormalities of chromosomes 21, 18, 13, X and Y chromosomes.
Since, none of these abnormalities are present you can safely plan your next pregnancy.

Thanks and take care
Dr Shailja Puri
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