Hello Metformin 1000 mg is used in following indications . 1 Type 2 diabetes mellitus ;adults Initiate therapy slowly in order to minimise adverse gastric events . Initially 500 mg tow or three times in day or 850 one or two times in day. Gradually increase the dose as required. 2 Poly Cystic Ovarian syndrome Adults initially 500 mg daily in the morning fro one week ;then 500 mg twice in day for one week , then 1500 -1700 mg daily in 2-3 divided dosage. Only there are two indications as far as known to me.